Simeprevir with sofosbuvir: risk of severe bradycardia and heart block when taken with amiodarone

Avoid concomitant use of amiodarone with simeprevir (Olysio▼) and sofosbuvir (Sovaldi▼) combination therapy, unless other antiarrhythmics cannot be given.

 

Letters sent to healthcare professionals in July 2015

Last month, letters were sent regarding SGLT2 inhibitors and Xgeva▼ (denosumab).

 

 

Posted on the UK MHRA website on 19 August 2015