SGLT2 inhibitors (canagliflozin, dapagliflozin, empagliflozin): risk of diabetic ketoacidosis
Test for raised ketones in patients with acidosis symptoms, even if plasma glucose levels are near-normal.
Endocrinology, diabetology and metabolism
High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk
EU review confirms that the cardiovascular risk of high-dose ibuprofen (≥2400mg/day) is similar to COX 2 inhibitors and diclofenac.
Cardiovascular disease and lipidology and 3 others
Intrauterine contraception: uterine perforation—updated information on risk factors
The most important risk factors for uterine perforation are insertion during lactation and insertion in the 36 weeks after giving birth.
Obstetrics, gynaecology and fertility
Survey of medicines safety communications
Please complete our survey on how we communicate medicines safety issues.
Hormonal pregnancy tests and birth defects: call for evidence
A group of independent experts will review all evidence provided; we will publish a report of the group’s findings.