SGLT2 inhibitors (canagliflozin, dapagliflozin, empagliflozin): risk of diabetic ketoacidosis

Test for raised ketones in patients with acidosis symptoms, even if plasma glucose levels are near-normal.

Endocrinology, diabetology and metabolism

 

High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk

EU review confirms that the cardiovascular risk of high-dose ibuprofen (≥2400mg/day) is similar to COX 2 inhibitors and diclofenac.

Cardiovascular disease and lipidology and 3 others

 

Intrauterine contraception: uterine perforation—updated information on risk factors

The most important risk factors for uterine perforation are insertion during lactation and insertion in the 36 weeks after giving birth.

Obstetrics, gynaecology and fertility

 

Survey of medicines safety communications

Please complete our survey on how we communicate medicines safety issues.

 

Hormonal pregnancy tests and birth defects: call for evidence

A group of independent experts will review all evidence provided; we will publish a report of the group’s findings.

 

Posted on the UK MHRA website on 26 June 2015