Drug safety advice
Dabigatran (Pradaxa) is now contraindicated in patients with prosthetic heart valves requiring anti-coagulant treatment related to their valve surgery. This is regardless of the length of time elapsed since valve replacement took place.
Aqueous cream may cause local skin reactions, such as stinging, burning, itching, and redness, when it is used as a leave-on emollient, particularly in children with atopic eczema. The reactions, which are not generally serious, often occur within 20 minutes of application but can occur later.
Botulinum toxin type B (Neurobloc) is indicated only for the treatment of cervical dystonia (torticollis) in adults. We recommend that prescribers adhere to the licensed indication as its safety outside these circumstances has not been established.
Other information from the MHRA
We have developed a learning module on benzodiazepines for clinical practitioners.