Levonorgestrel-containing emergency hormonal contraception: advice on interactions with hepatic enzyme inducers and contraceptive efficacy

Medicines or herbal remedies that induce CYP3A4 enzymes reduce blood levels of levonorgestrel, which may reduce emergency contraceptive efficacy.

Posaconazole (Noxafil): tablets and oral suspension are not directly interchangeable

Switching from posaconazole oral solution to tablets has resulted in cases of dose-related toxicity, whereas switching from tablets to oral solution has resulted in underdosing and lack of efficacy.

Idelalisib (Zydelig▼): updated indications and advice on minimising the risk of infection

Updated advice for healthcare professionals is available, after conclusion of a review of the safety of idelalisib, including the risk of infection.

Letters sent to healthcare professionals in August 2016

A summary of safety letters sent to healthcare professionals in August 2016

Posted on the UK MHRA website on 15 September 2016