Drug safety advice

Agomelatine (Valdoxan) may cause liver toxicity in some people. Test liver function before and during treatment.


We have received reports of Colobreathe (colistimethate sodium) capsules shattering when pierced by their inhaler device. The instructions for inhaler use have been revised to reduce this risk.



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Boceprevir and telaprevir are not recommended for patients who have a low platelet count or hypoalbuminaemia before starting either of these medicines. Boceprevir is also not recommended for patients who have coagulopathy before starting it.


An in-depth EU review of this risk has now been completed.


Use the minimum amount of chlorhexidine solution required and do not allow the solution to pool. Remove any excess solution and any soaked materials, drapes, or gowns from the skin.


Take care to tell people receiving blister packs containing a desiccant that the desiccant should not be swallowed.



Other information from the MHRA

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Posted on the UK MHRA website on 17 November 2014